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The quantification of patient's samples was evaluated according to different criteria such as dynamic range, sensitivity, efficacy of material recovery, reproducibility and convenience of sample handling.
Level of pain sensitivity, efficacy of analgesics, and susceptibility to developing chronic pain conditions are all subject to individual variability.
In keeping with the study objective we have determined through hypothetical, credible scenarios that the effectiveness of screening for AD is most influenced by: Screening test sensitivity, duration of test sensitivity, efficacy of AD prevention therapy, persistence on treatment, and initial screening age.
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As a sensitivity analysis, efficacy was also evaluated in the actual (observed) 12-month values.
Initially, we evaluated the sensitivity and efficacy of eight immunohistochemical markers for detection of early ON damage.
Allosteric modulators bind to regions that are distinct to the orthosteric binding site and can alter agonist sensitivity, agonist efficacy and channel kinetics.
To evaluate the sensitivity and efficacy of tumor labeling, the SDF-1-IRDye800CW SDF-1-IRDye800CW SDF-1-IRDye800CWSense 680® that targets mainly αVβ3/αVβ5 integrins of the tumor vasconjugate(Fig. 4).
Interestingly, γ-secretase inhibitors have the potential of increasing sensitivity and efficacy of other chemotherapeutic drugs as well as hormonal and targeted therapeutic agents.
In the specialty care setting where diagnostic certainty is crucial, we suspect that CT scan of the sinuses may be used at higher rates by the otolaryngologists for its high sensitivity and efficacy in ruling out chronic disease.
In summary, the predictive coding framework postulates that evoked responses correspond to prediction error that is explained away (within trial) during perception and is suppressed (between trials) by changes in synaptic sensitivity and efficacy during perceptual learning.
Attempts to improve screening sensitivity and efficacy in specific circumstances (younger age, adenocarcinoma) should not be based only on a more aggressive cytological approach (e.g. reduced rescreening interval, lower threshold for cytological abnormality prompting diagnostic assessment) but also consider the opportunity for adding HPV testing to Pap smear as a screening tool.
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CEO of Professional Science Editing for Scientists @ prosciediting.com