For instance, individual differences in reward sensitivity, drive, extrinsic versus intrinsic motivational orientation, and trait approach versus avoidance motivation have been found to influence responses to rewarding and aversive stimuli in the ventral striatum, putamen, and caudate (Beaver, Lawrence, Passamonti, & Calder, 2008; Costumero et al., 2013; Linke et al., 2010; Spielberg et al., 2012).
Wiseman himself came to fascinate me: through the sketchy historical record he emerged as strong, shrewd and ruthless - but also a man of feeling, even sensitivity, driven by passion to see his family prosper.
Therefore, design and synthesis of stimuli-responsive HBPs provide a robust tool for controlling the structure transition and creating the hierarchical sensitivity driven by different triggers.
One could argue that higher stress sensitivity drives the inability to experience positive feelings, or that stress sensitivity and positive feelings represent two extremes of one and the same continuum.
It is also worth noting, however, that Δ cpoB is sensitive to a number of other drugs and conditions, including almost all β-lactams to which Δ mrcB and Δ lpoB are sensitive (Nichols et al., 2010 and Figure 2A); these multiple shared sensitivities drive the strong correlation between phenotype profiles of Δ cpoB and Δ mrcB strains.
While early screens focused on drug sensitivities driven by single tumor-associated mutations, the latest efforts have highlighted growth sensitivities driven by multi-parametric biomarker signatures6 or differentiation-based vulnerabilities associated with lineage7, clearly illustrating the advantages of the continued expansion of screening formats and analytical capabilities.
Mechanistically our findings indicate that temperature-sensing TRP channels may not contain a specialized heat-sensor domain; instead, non-obligatory allosteric gating permits the intrinsic heat sensitivity to drive channel activation, allowing temperature-sensitive TRP channels to function as polymodal nociceptors.
Changes in nociceptor sensitivity may drive some of the pain of OA.
This has lead to the hypothesis that species- and population-level differences in opsin gene sequence and expression represent adaptations for foraging in either turbid or clear water and that these differences in spectral sensitivity may drive and/or maintain divergence in male coloration via sexual selection [ 11].
You finally hit the right theme when you say "our findings strongly indicate that the temperature-sensing TRP channels may not contain a specialized heat-sensor domain; instead, non-obligatory allosteric gating permits the intrinsic heat sensitivity to drive channel activation".
Runoff coefficient sensitivity is driven by elevation (temperature) driven controls on the proportion of precipitation falling as snow vs. rain, combined with decreasing evapotranspiration with increasing elevation.
