However, the major alleles of both HHEX SNPs were significantly correlated with reduced insulin secretion, as estimated from all three OGTT-derived indices of insulin secretion, even after adjustment for gender, age, BMI, and OGTT-derived insulin sensitivity (significant determinants of insulin secretion) (Table 3).
To determine the normal range of contrast sensitivity and its determinants through a population-based study in Shahroud, in northern Iran.
Due to the limited number of validated miRNA targets, the exact specificity and sensitivity of current determinants are unclear [ 20- 23]; however, estimates of precision of these determinants, alone or together, are typically reported to be about 50% at a sensitivity of 6-12% [ 24, 25], suggesting that sequence-based prediction methods are not fully capturing miRNA target preferences.
First-phase insulin secretion and hepatic insulin sensitivity are important determinants of the initial rate of rise in plasma glucose concentration after glucose ingestion (49).
Last, in multiple regression analyses, both VAT and insulin sensitivity were significant determinants of LDL and HDL particle size, whereas VAT and race were significant for VLDL particle size.
We used a time-series approach at the ZIP-code level to avoid confounding by intrinsic differences between sprayed and nonsprayed ZIP codes (e.g., in underlying asthma rates or patterns of public hospital use) and to maximize sensitivity to temporal determinants of asthma-related visit rates.
This was accomplished by comparing how the various organizations conceived of sensitive populations and defined determinants of sensitivity among subgroups.
In the fasting low-insulin state, hepatic insulin sensitivity is a determinant of glucose homeostasis.
Identifying the determinants of sensitivity to GNRH analogs would potentially allow sensitive tumors to be selected for treatment.
A rational use of ATRA in breast cancer requires the definition of the sensitive subtypes and the molecular determinants underlying retinoid sensitivity.
