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Inspired by the standard receiver operating characteristic (ROC) curve, the Feature-Response curve characterizes the sensitivity (coverage) of the sequence assembler as a function of its discrimination threshold (number of features).
These studies use techniques varying in sensitivity, coverage, sequence bias and amounts of DNA required.
This is mostly because of their sensitivity, coverage and the well-curated functional information associated with known motifs or domains.
This leads to a sensitivity (coverage) of 1 and a specificity of 0, and the positive predictive value converges to the ratio of operonic/all genes.
This largely is related to technical constraints, because whole-proteome expression profiling currently cannot be done with the same degree of sensitivity, coverage, and throughput as mRNA profiling.
This demonstrates that high operon prediction accuracy is obtained by maximising sensitivity (coverage) of the TFBS prediction, albeit at the expense of TFBS prediction specificity, and without over-predicting TFBSs either.
Similar(53)
Jackknife manipulations (systematic omission of ecologic dimensions to assess sensitivity to coverage density) can, to some degree, help in assessing sensitivity to coverage completeness (42), but dimensions more important than the set actually used may exist.
With the designed system, PAVI revealed satisfactory imaging depth and sensitivity for coverage of the entire breast when imaged from both sides in the mammographic geometry with mild compression.
Predicted voltages for a uniform earth (homogeneous and isotropic) potential model (finite difference) were subtracted from each data set (for its respective current source location), and the voltage residuals superposed to create new data sets with greater measurement sensitivity and coverage, to aid in interpretation.
As expected from the results of the original SNAP publication (23), higher thresholds result in greater specificity ("accuracy") in identifying functionally nonneutral substitutions while potentially reducing the total number of nonneutrals identified (lower sensitivity/"coverage"; Eq. 1).
Definition of the sensitivity and coverage remain the same.
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