Most of the metabolites were associated with both insulin sensitivity and total insulin secretion during OGTT; however, all associations with insulin secretion vanished when conditioning on insulin sensitivity, whereas the insulin sensitivity associations remained significant upon conditioning on insulin secretion.
Further, given that magnesium might influence colorectal cancer risk by improving insulin sensitivity, associations with magnesium intake might be stronger among overweight/obese individuals with possible insulin resistance, as suggested in one prior study (van den Brandt et al, 2007).
It is much more sensitive than linkage analysis to small effects; however, the sensitivity of association analysis is counteracted by the fact that it is effective only if the marker is very close to the actual risk gene.
Similarly, identical markers or tightly linked ones (redundancy) may reduce the sensitivity of association mapping.
Zheng et al. (abstract 1263) reported that 40% calorie restriction of obese Zuker rats improved hepatic insulin sensitivity in association with reduction in extracellular signal-regulated kinase activity.
In conclusion, we cannot confirm that HDL lipoproteins directly exert a relevant role in modulating insulin sensitivity, the association between the two being explained mostly by confounders and in part by adiponectin.
This research evaluated the extent to which reward sensitivity demonstrated associations with binge and purge behavior frequency.
In sensitivity analyses, associations of long-term exposures were also investigated after adjustment for recent exposures.
As a secondary aim, we compared the sensitivity of associations with risk factors including age, sex, smoking history and socioeconomic position.
Platinum sensitivity showed associations with small RT at the same P level as CR; PS was also associated with FIGO stage IIB or IIC in the whole group (P=0.02) and in the TP53 group (P=0.05), as well as with patient age in the whole group only (P=0.017).
