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Initially, we evaluated the sensitivity and efficacy of eight immunohistochemical markers for detection of early ON damage.
Interestingly, γ-secretase inhibitors have the potential of increasing sensitivity and efficacy of other chemotherapeutic drugs as well as hormonal and targeted therapeutic agents.
In the specialty care setting where diagnostic certainty is crucial, we suspect that CT scan of the sinuses may be used at higher rates by the otolaryngologists for its high sensitivity and efficacy in ruling out chronic disease.
To evaluate the sensitivity and efficacy of tumor labeling, the SDF-1-IRDye800CW SDF-1-IRDye800CW SDF-1-IRDye800CWSense 680® that targets mainly αVβ3/αVβ5 integrins of the tumor vasconjugate(Fig. 4).
In summary, the predictive coding framework postulates that evoked responses correspond to prediction error that is explained away (within trial) during perception and is suppressed (between trials) by changes in synaptic sensitivity and efficacy during perceptual learning.
Attempts to improve screening sensitivity and efficacy in specific circumstances (younger age, adenocarcinoma) should not be based only on a more aggressive cytological approach (e.g. reduced rescreening interval, lower threshold for cytological abnormality prompting diagnostic assessment) but also consider the opportunity for adding HPV testing to Pap smear as a screening tool.
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In this way, the diagnostic and therapeutic indications will be broadened to include more tumor types, while diagnostic sensitivity and therapeutic efficacy will improve.
However, the diagnostic sensitivity and therapeutic efficacy of nanoparticles as well as the heterogeneity of tumors pose tremendous challenges for clinical imaging-guided PDT treatment.
In summary, translation of the concept of in situ stabilization of biodegradable peptide radioligands to improve tumor targeting and hence diagnostic sensitivity and therapeutic efficacy, from the preclinical setting into patients, poses certain challenges that need to be competently addressed.
These results suggest that specific placement of thiophosphates could play an important role in the development of siRNAs as therapeutics by engineering in properties such as strength of binding, nuclease sensitivity, and ultimately efficacy.
Our results indicate that the STK11 rSNP11699 SNP influences both insulin sensitivity and metformin efficacy in hyperinsulinemic girls with androgen excess.
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CEO of Professional Science Editing for Scientists @ prosciediting.com