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Because the experimental validation makes use of the enhancements in sensitivity achievable by the use of optical cavities, the theory and simulation assume an intra-cavity probe.
The V parameter of microstructured optical fibers and the confinement loss requirement set a limit on the maximum sensitivity achievable from index-guiding microstructured fibers.
Spitzer combines the intrinsic sensitivity achievable with a cryogenic telescope in space with the great imaging and spectroscopic power of modern detector arrays to provide the user community with huge gains in capability for exploration of the cosmos in the infrared.
Recall that a ROC curve shows all possible couples (1 - specificity; sensitivity) achievable by a prediction model when varying the threshold probability.
The maximum sensitivity achievable was thus ~0.0004% (4E−6) based on the total amount of 1.5 μg of DNA, corresponding to ~240 000 nucleated cells.
However, amplification of submicroliter starting volumes of a target [ 13, 14] limits the actual sensitivity achievable because existing devices have not been integrated with an NA concentration step.
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In recent years there has been increasing interest in the use of nanoparticles (NP) coupled with silver staining for diagnostic applications [ 31- 33] due to the higher sensitivities achievable by this approach compared with the fluorescent dyes that are commonly used in microarray assays.
Then, the method is applied to finite-element models of a cantilevered beam to demonstrate the magnitude of sensitivity enhancement achievable for modest, local damage.
It can be improved with optimized sample preparation, but, when compared to ATR mode, it still does not compete in terms of sensitivity and achievable lateral resolution [26].
The highest sensitivity is achievable by PCR-based assays detecting recurrent molecular aberrations such as fusion transcripts and mutations.
When higher numbers of replicates are tested, higher sensitivities are achievable depending on the total number of templates assessed.
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