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The results concur with those of other studies but are highly sensitive to utility values used in the analysis.
One-way sensitivity analyses showed incremental costs to be most sensitive to polypill adherence, discount rate and revascularisation costs, while incremental QALYs and ICERs were most sensitive to utility values of patients on secondary prevention and patients having had a second MI.
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ICER is also sensitive to utilities and to PFS while it's less sensitive to OS (Table 6).
While these methods are likely to be more sensitive to the utility impact of specific disease and treatment characteristics, their primary limitation in the HTA context is that comparability to utilities derived from generic preference-based instruments is uncertain.
Imatinib's cost-effectiveness was sensitive to patient utility values.
Evidence from the DMO Evidence Review Group report suggests the ICER is sensitive to the utility values used.
The QALY estimates were relatively sensitive to the utility of being well after surgery to treat extracapsular fractures.
ICERs were most sensitive to the utility of severe pain, model duration, and the success rate for non-surgical treatment.
The cost-effectiveness ratio was not sensitive to the utility of being in the "hospital" or "discharged" states.
Our findings are most sensitive to the utility assumptions, and the probabilities of having either a satisfactory or unsatisfactory outcome.
Our economic model is found sensitive to the utility weight for healthy state under chemoprevention, the discount rate and the cost of chemoprevention, in addition to the probabilities of transition to invasive breast cancer, endometrial cancer, or hip fracture.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com