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However, these are not sufficiently sensitive to track virions rather than transgenes in vivo.
Studies have suggested that tissue oxygenation (StO2) measured on the thenar muscle is not sensitive to track acute changes in hemodynamics due to reductions in central blood volume.
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Pollution-induced community tolerance (PICT) has been suggested as a sensitive tool to track changes in community function (and therefore indicative of structural changes) that can be attributed to toxic substances.
A team led by Fulvio Mavilio of the San Raffaele-Telethon Institute for Gene Therapy in Milan suspected, however, that those experiments may not have been sensitive enough to track the fate of transplanted bone marrow.
We thus show that UCPs are sensitive enough to track the amount of body mass variation typically associated with the behavioural and reproductive strategies seen in macaques.
Since hemodynamic changes reflect the integrated neural activity within seconds, fMRI and PET may not be sensitive enough to track the possibly rapid and transient neuronal correlates of this disorder, and may not be able to separate early effects from later, possibly compensatory processes in identical brain areas.
In the era of personalized medicine with more and more patient specific targeted therapies being used, we need reliable and sensitive biomarkers to track the disease and to develop therapies during the course of treatment.
Even though LF1 is not sensitive enough to track toxicologically relevant concentrations (15 ppb per EPA standards), studies using confocal microscopy revealed that it is capable of monitoring changes in cytosolic Pb2+ within living cells.
The trend of new or incident infections, especially in young people who have recently become sexually active, is the most sensitive marker to track the course of the HIV epidemic.
As these cognitive-enhancing therapeutics enter clinical testing, the need for quantitative and sensitive biomarkers to track cognitive function for both patient selection and for monitoring therapeutic response is critical.
While independent structural corroboration is inaccessible because these junctions are hidden beneath much bigger nanoparticles, we demonstrate here that optics provides an exquisitely sensitive tool to track material dynamics on the nanoscale.
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