Together, these data demonstrate that not only can GRPR expression transform cells, but these cells then become more sensitive to substance P-analogue-induced cell death.
Instead of removing those state-specific genes with too detrimental an effect, natural selection may lead to clearance of substance S. As a result, the detrimental effect of all state-specific genes sensitive to substance S is forestalled, and the rate of senescence decreased.
Chemical receptors, or chemoreceptors, are sensitive to substances taken into the mouth (taste or gustatory receptors), inhaled through the nose (smell or olfactory receptors), or found in the body itself (detectors of glucose or of acid-base balance in the blood).
Allergic reactions are sensitive to substances called allergens that come into contact with the skin, nose, eyes, respiratory tract, and gastrointestinal tract.
Identifying similarities in allergens can be used clinically, to alert patients who are sensitive to substances known to trigger extreme allergic reactions, such as peanuts, shellfish, or latex, to the presence of similar proteins in different sources.
The protein derived from this gene is known, from laboratory experiments, to be sensitive to a substance called phenylthiocarbamide (PTC).
The principal finding of the exposure of the co-culture to 2,5-hexanedione was that not only toxicity profiles of two different doses could be discriminated, but also that the co-cultures were more sensitive to the substance compared to respective single-tissue cultures in the multi-organ-chip.
We selected V. vulnificus CZ-A2 as the target strain for screening of Bacillus strains having anti-Vibrio activity, and for follow-up studies of the mechanism of H2 activity, because CZ-A2 was highly sensitive to the substance present in H2 CFS.
The substrate-sensitive sensor should not only be highly sensitive to the substance of interest, but also nonsensitive to all other chemical and physical interferents.
According to other authors, GCC reduction observed after intravitreal ranibizumab may result from a progressive arteriolar vasoconstriction, a consequent retinal ischemia associated with glutamate release that may damage ganglion cells, particularly sensitive to this substance [ 27– 29].
In addition the esophageal mucosa, which is particularly sensitive to acidic substances, easily induces regurgitation in response to such substances [ 5, 12], leading to aspiration pneumonia.
