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We show that current non-parametric covariation statistics are sensitive to sequence misalignments and that this sensitivity can be used to identify systematic alignment errors.
Combined, these studies show that the insertion boundaries of TM helices are very sensitive to sequence, and can be altered even by weakly hydrophilic residues.
Therefore, the predicted secondary structures of a target exon were not sensitive to sequence length of the window of analysis.
These data allow us to infer the relationships between experimentally important strains of yeast and provide insight for experimental designs that are sensitive to sequence variation.
Finally we describe two non-parametric covariation statistics that are less sensitive to sequence alignment errors than those described previously in the literature.
However, given the high degree of overlap between the SNAP score distributions of variable and non-variable exons, it is not possible to predict a priori whether an individual SNAP gene model is sensitive to sequence polymorphisms.
Similar(36)
The carbonyl carbon group of M and H gave resonance signals with different chemical shift sensitive to sequences of tactic pentads, independently of the chemical composition.
Because ABySS can be very sensitive to sequencing errors such as short indels, when using raw 454 reads in ABySS, custom Perl scripts were used to remove any raw 454 read that had homopolymers exceeding 10 bases (all 454 homopolymer error reads cannot be removed but can be minimized).
Thus, the number of OTUs is sensitive to sequencing error of 454.
Especially the latter application is extremely sensitive to sequencing errors and artificially duplicated reads.
When the sequencing process becomes more noisy, the KL distances appears to be less sensitive to sequencing errors.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com