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Thereby the expression of these genes becomes sensitive to repression by near-by heterochromatin [22].
It is possible that the disruption of auto-repression causes increased Myc levels at a time when these genes are sensitive to repression by Myc.
HSV-1 viruses that bear null mutations in the ICP0 gene are acutely sensitive to repression by interferon-α/β [35], [36], are avirulent in immunocompetent mice and lymphocyte-deficient rag2−/− mice [37], and elicit a nearly sterilizing immune response against wild-type HSV-1 [37].
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The wild-type lac promoter was also replaced with the two-fold stronger lacUV5 promoter [13], which also displays significantly lower sensitivity to intracellular levels of cAMP, thereby being less sensitive to glucose repression.
Nonetheless, the hyper-active Adr1c proteins are still sensitive to glucose repression and respond to activation of Snf1 in repressing conditions, pointing to regulation beyond the potential Ser230 modification [8], [10].
Third, the consumption of these sugars is less sensitive to glucose repression.
Therefore, these transgenes are not sensitive to the repression exerted by the S genetic background.
The 3′UTR from the Bearded (Brd ) gene renders eGFP expression sensitive to miRNA repression.
This may be explained by the RED production being sensitive to phosphate repression, thus still being dependent on phosphate reduction in addition to a reduced growth rate, as also observed for a number of other antibiotics [ 31, 32].
Indeed, nineteen targets located on chromosomes 1, 2 and 3 were tested and all were sensitive to trans-repression.
These include: whether suppressing c-FLIP in non-tumour cells compromises their viability; whether a broad range of breast cancer subtypes are affected by c-FLIP sensitization; and of particular clinical significance, whether the normally chemo-resistant CSC sub-populations within each of these heterogeneous subtypes are sensitive to de-repression of this apoptotic pathway.
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CEO of Professional Science Editing for Scientists @ prosciediting.com