Sentence examples for sensitive to linkage from inspiring English sources

The burden test used in our genome-wide burden analysis is sensitive to linkage disequilibrium (increased type I error rate).

Although we found that the method is reasonably robust to violations of four key assumptions, it can be highly sensitive to uneven linkage disequilibrium (LD) between SNPs: contributions to h2 are overestimated from causal variants in regions of high LD and are underestimated in regions of low LD.

On the other hand, hierarchical clustering methods are strongly sensitive to the linkage method adopted and, in addition, their standard output, the tree diagram, is not adequate to represent a relational network.

Habier et al. [ 6, 9] demonstrated how the decaying genetic relationship across generations affected RR prediction accuracy more than that obtained with Bayes-B because RR is more sensitive to family linkage.

Our findings suggest that the most commonly used single-point methods (FPLINK and FACD) do not measure much more than the simple proportion of heterozygous loci (multilocus heterozygosity), but they do have the advantage of not being sensitive to the presence of linkage disequilibrium.

Some proteins contain few linkages sensitive to tryptic digestion, and can escape identification by peptide mass mapping.

In this strategy, base-labile main chain protection is combined with side-chain protecting groups and resin linkages sensitive to TFA treatment (Scheme 2), thereby bypassing the hazardous HF cleavage step commonly employed in Boc-SPPS.

Since the optimized kinematic error is very sensitive to the variations of the linkage parameters, the kinematic and post-optimal sensitivity optimization of the steering linkage is performed in an integrated manner.

This occurs because high innovation backward linkages are sensitive to productivity changes in other sectors.

Both the Lys48 and Lys 63 linkages were sensitive to treatment with wild-type USP45 (Supplementary Fig S5C).

The gamma coefficients indicated that the single linkage grouping technique was more sensitive to the type of data errors employed than the complete linkage technique.