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These data indicate that FAD can preferentially kill cancer cells and that significant numbers of human cancers are sensitive to FAD.
As shown in Supplementary Figure S2, cell lines that are sensitive to FAD exhibit high level of XBP1 splicing after FAD treatment whereas cell lines that are resistant to FAD exhibit little FAD-induced XBP1 splicing (compare Supplementary Figures S1 and S2a).
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Although non-transformed cells are resistant to FAD treatment, most of the cancer cells, with the exception of MCF7, are sensitive to 6 μM of FAD (Supplementary Figure S1).
The results showed that the mRNA levels of most selected genes were significantly or very significantly up-regulated under all stress conditions, with all genes were up-regulated under Fe + AC and HT conditions, and some genes, such as FATA, SAD and FAD, were more sensitive to treatments.
As seen from Figure 6, in spring the LLM were found to be highly sensitive to Cd2+ when energized by both NAD- and FAD-depended substrates.
However, for cysteine residues sensitive to nitrosative stress, such as Cys417 and Cys402, both in the FAD-binding domain, S-oxidation accompanied S-nitrosylation.
He's sensitive to that.
Sensitive to feeling left out?
"I'm sensitive to that.
It is sensitive to ambiguities.
It is sensitive to news.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com