Anion conducting networks were obtained by the incorporation of two cyclic diamines named 1,4-diazabicyclo-[2.2.2]-octane (DABCO) and 1-azabicyclo-[2.2.2]-octane 1-azabicyclo-[2.2.2]-octane 1-azabicyclo-[2.2.2]-octane 1-azabicyclo-[2.2.2]-octane
Collectively, these observations suggest examination of other CYP2C9 substrates sensitive to first-pass elimination, such as fluvastatin, to understand fully the milk thistle-CYP2C9 interaction potential.
Identifying them would allow researchers to rigorously test the model by showing that cells are less sensitive to bortezomib upon elimination of the modification.
Warfarin is not sensitive to first-pass elimination and is cleared only upon subsequent passages through the liver, at which time any reversible inhibition of CYP2C9 by silybin A and silybin B would be abated.
Oxidation produces dialdehydes that are highly sensitive to alkaline β-elimination, even under physiological conditions (pH 7.4, 37 °C).
Because Betti numbers for networks are sensitive to individual as well as to elimination of multiple protein inhibitions, they can be used for defining combinatorial therapies.
The selection of terms for the model was not sensitive to model selection process (backward elimination or forward selection) or type of model (linear or ordinal).
However, the feature elimination method is sensitive to small perturbations of the training set.
In healthy subjects, ICG elimination has been sensitive to show effects of the circadian rhythm [ 21], posture [ 22], food intake [ 23], age [ 24] and various medications [ 12- 14, 22, 25] on the hepatic blood flow.
Another hypothesis explaining the change in methylation status is that tumor cells with promoter methylation at GSTP1 or RARB2 are more sensitive to chemotherapy, leading to their earlier elimination.
