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Exact(15)
The data in Table 2 demonstrated that nonprotein thiols were more sensitive to depletion by NEM; all nonprotein thiols were effectively depleted by 30 μM NEM, whereas 500 μM NEM was needed to completely deplete protein thiols (Table 2).
Penguins also are very sensitive to depletion of local fish populations by humans.
These data indicate that Tat function is especially sensitive to depletion of either Cyclin T1 or CDK11.
Thus ovarian tumor cells with amplification at 19q12 are specifically sensitive to depletion of Cyclin E1, compared with unamplified lines.
To determine whether PKCε is specifically required for RVFV MP12 infection, or generally required for all viruses, we tested whether poliovirus infection was sensitive to depletion of this factor.
When an inducible system was developed a key developmental system, hematopoiesis, was found to be sensitive to depletion of THOC5/FMIP.
Similar(45)
For example, some cells are sensitive to glucose depletion, while other cells are sensitive to glutamine depletion.
It has been shown that circulating B cells are most sensitive to rapid depletion as compared to the slow and incomplete depletion of B cells in spleen, lymph nodes, or bone marrow (BM).
To help identify these substrates, it would be of interest to compare the pattern of proteins that are destabilized or more ubiquitinated upon USP19 silencing in cells whose growth is sensitive to USP19 depletion with the pattern of such proteins found in cells whose growth is insensitive to USP19 depletion.
Interestingly, there was also no correlation between the V600E BRAF status of each line and sensitivity to MIF depletion since the V600E BRAF positive cell lines MelCV and MelRMu were amongst the most sensitive to MIF depletion (refer Discussion).
BRCA1-depleted breast cancer cells have previously been shown to be sensitive to CDK2 depletion or inhibition (Deans et al, 2006).
Related(20)
sensitive to destruction
sensitive to loss
sensitive to erosion
sensitive to overexploitation
sensitive to shrinkage
vulnerable to depletion
susceptible to depletion
sensitive to corrosion
sensitive to drain
sensitive to decrease
sensitive to feeling
sensitive to contact
sensitive to alcohol
sensitive to news
sensitive to oil
sensitive to pain
sensitive to oxygen
sensitive to acidity
sensitive to sulfur
sensitive to interest
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