Sentence examples for sensitive to cleavage from inspiring English sources
A common method for introducing degradability is the inclusion of oligopeptides sensitive to cleavage by matrix metalloproteinases (MMPs), enabling cell-mediated remodeling and migration within the material.
The His12/Leu13 bond is sensitive to cleavage by neutral endopeptidase [14], so substitution of Leu for the non-natural Cha and Sta (see below) has been suggested to increase in vivo stability [15].
Dox was conjugated to the Fe3O4-CHI nanoparticles via a glutaraldehyde cross linker with the imine (CN) bond, which is sensitive to cleavage in the pH range of 4.4 6.4.
Amino acid residue 797 is also sensitive to cleavage by trypsin, plasmin and TMPRSS11a proteases.
We then determined whether the fusion molecules could generate FRET signals that were sensitive to cleavage (Fig. 2A).
Incubation of extracts containing HA-TrkB-FL with calpain revealed that, contrary to TrkB-T1, recombinant and endogenous TrkB-FL were sensitive to cleavage.
Large secondary structures formed by pairing of adjacent REPs may have functional relevance at the RNA level, and differences in the extent of base pairing between homodimers and heterodimers may determine whether the RNA hairpins formed are sensitive or resistant to cleavage by specific endoribonucleases [ 17, 19].
The C346 but not the C370 RNA was highly sensitive to intrinsic cleavage in halted ECs; the positions of cleavage suggested that halted C346 ECs spontaneously backtracked by 4 6 nt.
Since one of the cleavage sites remained unchanged, we expected that these V5-MKK4cr and V5-MKK7cr mutantshouldld be still sensitive to LF cleavage.
The production of multiepitope molecules based on several peptides linked by sequences sensitive to proteasomal cleavage represents a promising new tool for the improvement of cancer immunotherapy.
The effect of substitution R55W could be exerted during polyprotein processing, by rendering 2C more sensitive to polyprotein cleavage mediated by 3C.
