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L. mexicana will also infect mice, and although the immunological factors determining resistance and susceptibility are not as well-defined as in L. major [ 24- 26], it offers the advantage of slower in vivo kinetics and consequently is anticipated to be more sensitive to altering factors.
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One neuronal function that is particularly sensitive to altered P/Q signaling is the precise timing of spikes.
According to Ganzhorn and Schmid [ 63], the species is extremely sensitive to altered environmental conditions.
Stimulus-specific putamen/pallidal responses in obese people with binge eating are sensitive to altered mu-opioid function.
We also identify several key genes within the module that are sensitive to altered Cd44 expression and likely to affect atherosclerosis risk.
Cells of the immune system are highly sensitive to altered gravity, and the monocyte as well as the macrophage function is proven to be impaired under microgravity conditions.
Androgens are critical for specifying prostate development, with the fetal prostate sensitive to altered hormone levels and endocrine-disrupting chemicals (EDCs) that exhibit estrogenic or antiandrogenic properties.
Alternatively, phenotypes arising from genes whose function is sensitive to altered copy number will incur an ascertainment bias of these deletions.
In particular, fishing may lead to changes in life history traits, such as age and size at maturation, because these traits are especially sensitive to altered mortality schedules (Stearns 1992).
We used well-established tests for locomotor activity, novel object exploration and executive functions that have been previously shown to be sensitive to altered AMPA receptor signaling (14, 15).
In mice heterozygous for Tbx1, ganglia fusion has only been observed for the most caudal nerves, indicating that caudal arches are more sensitive to altered Tbx1 dose than rostral pharyngeal structures (79).
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