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Consequently, expression of these oncogenic mRNAs is preferentially and dis-proportionately affected by eIF4E availability and is sensitive to alteration of its level.
Knockdown experiments using siRNA suggested that this phosphorylation is sensitive to alteration of the tertiary structure of the p62-Keap1 complex.
It is possible that SMN2 exon 7 splicing in motor neurons is especially sensitive to alteration in snRNPs, further depleting SMN protein and contributing to motor neuron degeneration in SMA.
Although we could not detect an obvious lack of phosphorylation in any of the rfa2 -extensive mutants in response to DNA damage, we did observe that certain regions of the Rfa2 NT were more sensitive to alteration than others.
We used distributions with mean between 0 and 1 and standard deviation between 0.03 and 1. Altering parameters which control the magnitude of connection strengths has little effect on the dynamics, on average: neither the fraction of runs which reach steady state nor the average period is sensitive to alteration in the mean or standard deviation of the connection strength distribution.
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The central nervous system is directly sensitive to alterations in oxygen delivery 8 and afferent signals from the muscles can also alter central neural function.
Receptors located in the large arteries and the kidneys are sensitive to alterations in cardiac function.
Both the excitation and propagation mechanisms are sensitive to alterations in the ion concentration of the extracellular and intracellular fluid, as well as drugs that might alter the carriers or channels associated with these ions.
MTR is sensitive to alterations in the macromolecule composition.
Initial portions of the kinetic curves are most sensitive to alterations in SCWA compositions.
Hence, the pre-edge peak intensity is very sensitive to alterations in the local geometrical symmetry [21].
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