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The most sensitive strains are hfi1Δ and spt20Δ, displaying sensitivity at 25 μM CG-1521.
Introduction: Harboring sensitive strains may prevent acquisition of resistant pathogens by competing for colonization of ecological niches.
Stochastic phenotype switching allows producers to outcompete sensitive strains since colicin release frees up vacancy.
Competition may be relevant to decolonization strategies that eliminate sensitive strains and may predispose to acquiring resistant strains in high-endemic settings.
It posses remarkable activity against both chloroquinine resistant as well as chloroquinine sensitive strains of Plasmodium falciparum.
This tolerant strain also showed higher ethanol productivity, biomass formation and alcohol dehydrogenase activity comparing to sensitive strains.
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Lawrence, C.W. & Christensen, R. UV mutagenesis in radiation-sensitive strains of yeast.
Crossing drug-resistant parasites with drug-sensitive strains provides a powerful way to identify the genes that control resistance, and should reveal ways to combat it.
In that scenario, resistant strains can spread rapidly if widespread use of anti-malarial drugs quickly kills off drug-sensitive strains.
The polyamine appendage at the C-terminal, on the other hand, improved the activity against vancomycin-sensitive strains.
Temperature-sensitive strains can reproduce only at 33°C and are not pathogenic to humans.
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