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The plethora of intracellular signaling cascades that can impact renal cystic development suggest an exquisitely sensitive requirement for integrated downstream transduction and provide potential targets for therapeutic intervention.
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Mutations in these genes are not known to be temperature sensitive, suggesting that they uncover a temperature-sensitive requirement for H3K4 demethylase activity.
Because swsn-2.1 and swsn-2.2 are paralogs, this may reflect a dose-sensitive requirement for C. elegans BAF60 in gonadogenesis.
Impaired expression of PTF1-network components, lowering the threshold for KRAS-mediate reprogramming and transformation, might explain the dosage-sensitive requirement for Nr5a2 in preventing PanIN formation (Flandez et al., 2014; von Figura et al., 2014b).
Due to ethical constraints of performing placebo controlled trials and the resultant trend towards comparator controlled trials, the requirement for sensitive endpoints is greater than ever.
Our results in BT474-HR cells revealed that the hallmark of PR role in Tam-sensitive cells is the requirement for PR to crosstalk with unliganded ERα to activate the Src/p42/p44MAPKs cascade leading to c-Jun phosphorylation and AP-1/PR complex formation.
In the mission-critical CPS application scenes, control of physical devices is more time sensitive and has a strict requirement for transmission timeliness.
In order to improve survival outcome and administer the most effective treatment, there is a requirement for more sensitive tumor markers than those currently available.
These results are consistent with a requirement for metronidazole-sensitive colonic bacteria for compound K synthesis.
While schools and colleges understand and are sensitive to dress requirements for students from particular religious communities, including the Islamic head covering, it is widely understood that teachers and students require full eye contact in the classroom.
In accordance with our hypothesis of a role for CD47 in collagen I-induced COX-2 expression we found a requirement for a PTX sensitive G-protein that we have identified as Gαi3.
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CEO of Professional Science Editing for Scientists @ prosciediting.com