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A high Ca++ sensitivity of the diffusely distributed CamMR would result in prolonged, EGTA-sensitive release.
The enhanced intracellular delivery effective therapy may result from the pH-sensitive release.
Meanwhile, the nanocapsules exhibited a high drug loading and pH-sensitive release property for doxorubicin hydrochloride.
The PLGA/HP55 nanoparticles exhibited an excellent insulin entrapment ability and a good pH-sensitive release behavior.
In present investigation, two glucose based smart tumor-targeted drug delivery systems coupled with enzyme-sensitive release strategy are introduced.
Hollow mesoporous zirconia (hmZrO2) nanocapsules loaded with biomimetic precursors exhibited pH-sensitive release capability and good biocompatibility.
In addition, polymer microparticles loaded with calcitonin and interferon β exhibited complexation/decomplexation and pH-sensitive release behavior.
Thus, the effective therapy may result from the enhanced intracellular delivery, the pH-sensitive release, and protection of etoposide by ECCNSs.
The HTCP NPs of high, moderate and low docetaxel versus cisplatin ratio were prepared by the nanoprecipitation method, which showed a pH-sensitive release for both anticancer drugs.
The in vitro characterization showed a successful incorporation of FK506-NP and strongly pH-sensitive release kinetics of both NP and drug.
In vitro test of ibuprofen (IBU) loading and release exhibited a pronounced transition at around 17 °C, indicating a typical thermo-sensitive release property for this delivery system.
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