The design rationale of reduction-sensitive polymers and conjugates usually involves incorporation of disulfide linkage(s) in the main chain, at the side chain, or in the cross-linker.
Deamidation via cyclization into aspartate threatens integrity of asparagine, a process which is sensitive to higher temperature, providing a rationale for an asparagine excess in psychrophiles.
Along the line of speculation, if only very little FU is sufficient, these data may provide additional rationale to identify the sensitive patient population.
Third, this rationale is not sufficiently sensitive to the importance of evolutionary and ecological considerations – of the relationship between these individuals and the evolving populations of which they are a part and in which they share some value.
The observation that cancer cells harbouring CCNE1 gene amplification are sensitive to CDK2 inhibitors provides a rationale for the testing of these chemical inhibitors in a subgroup of patients with ER-negative grade III breast cancers.
Recent data indicate that calcineurin inhibitors activate the thiazide-sensitive sodium chloride cotransporter, providing further rationale to test thiazides in this population.
Ms. Meksis, offering a rationale for the purchase of sensitive or controversial material, said, "Just because I buy material on the Third Reich doesn't make me a Nazi skinhead".
Both approaches show that ETw is not sensitive to soil properties, which provides a rationale for combining historical data from different locations to study the impact of climate variability on evapotranspiration processes at annual time scales.
This method of describing molecular topologies is sensitive to conformational changes, which was the rationale behind including ligand structural data from the PDB only, as such data would harbour the additional information of the biologically relevant conformer.
A further challenge is that the self-ownership rationale fails to clarify why touching sensitive areas of the body without consent seems worse than touching less sensitive areas without consent.
