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We first assess whether structurally sensitive nucleotide sites are more conserved than non-sensitive sites.
Our results suggest a universal trend of increased nucleotide conservation at structurally sensitive nucleotide sites.
We employed Mantel-Haenszel procedure [ 34, 35] to determine whether structurally sensitive nucleotide sites are more evolutionarily conserved.
OR MH greater than 1.0 signifies that structurally sensitive nucleotide sites tend to be more conserved than non-sensitive sites.
Using both the Mantel-Haenszel procedure and association test, we found structurally sensitive nucleotide sites evolved more slowly than non-sensitive sites in all four organisms.
Persistent infection of SFTSV in animals has not been shown to date, and a more sensitive nucleotide acid detection method may help to define whether SFTSV infection is prolonged in domestic animals.
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Smith et al. have confirmed the specific MgATP binding and the vanadate-dependent, N-ethylmaleimide-sensitive nucleotide trapping activity of ABCB4, using the radiolabeled photoaffinity ATP analog [ α-P]8-azido-ATP and insect Sf9 cell membranes overexpressing ABCB4 [ 35].
The so-called switch I and switch II regions of small GTPases, which are sensitive to nucleotide hydrolysis and create a dependency on nucleotide status for the interaction of GTPases with their effectors (Vetter and Wittinghofer, 2001; Cherfils and Zeghouf, 2013), are also profoundly modified in CENP-M.
In this work we described a highly sensitive single nucleotide polymorphisms (SNPs) typing method with detection of 42 mitochondrial DNA (mtDNA) SNPs in a single PCR and SNaPshot multiplex reaction in order to allow haplogroup classification in Latin American admixture population.
In this study, the haplotype sensitive single nucleotide polymorphisms (SNPs) of FGFROP2/wit3.0 were evaluated in long-term edentulous subjects.
This might explain why AON efficiency is more sensitive to nucleotide changes at the 3' end than 5' end of its target site [65].
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