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The use of a treadmill to gather data for gait analysis in mice is a convenient, sensitive method to evaluate motor performance.
Here we propose a simple, cheap, reliable, time-saving, and highly sensitive method to evaluate a given gene-editing tool based on its capacity to induce chromosomal translocations when combined with a reference engineered nuclease.
By combining FDG and the microfluidic device, we developed a novel and highly sensitive method to evaluate the efflux inhibitory activities of compounds against P. aeruginosa MexB and MexY in E. coli, and clarified difference of action mechanism between two inhibitors, pyridopyrimidine (D13-9001) [25] and PAβN (Figure 1).
We next utilized fluorescence polarization technology, a sensitive method to evaluate interactions between proteins and peptides [ 27].
In another study, Nagrath et al identified a highly sensitive method to evaluate circulating tumor cells from blood samples, which may correlate with tumor response to therapy [ 36].
A very sensitive method to evaluate the antitumor activity of DAC is to determine the cloning efficiency of tumor cells in vitro after an in vivo treatment.
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The most attractive application of gene editing technology in human gene therapy is largely restrained by the lack of sensitive methods to evaluate the off-target effects of genetically engineered nucleases.
Furthermore, they used a more sensitive method to measure PCO2.
This work describes the development of a sensitive HPLC-MS based method to evaluate the use of Phe and its reaction products as a way to probe.
The results indicate that a salt sales survey could serve as a simple, sensitive and cost-effective method to evaluate community-based salt reduction programs in which salt is mainly added by the consumers.
Newer technologies can often provide increasingly sensitive diagnostic tests; however, there is no straightforward method to evaluate their performance when they are more sensitive than the reference standard.
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