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One of the more bizarre moments the tournament came during Daniela Hantuchova's tearful exit from the singles, with the following commentary: 'That's the last thing we need now, a mobile phone ringing.' Now there are times when you might use such a line, if you were a neurosurgeon about to operate on a patient hooked up to sensitive machinery, but for a tennis match?
Hirobe doesn't let visitors anywhere near the sensitive machinery that squirts liquid crystals onto the surfaces of the enormous glass sheets.
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Thus, the concerted histone expression defects upon redox perturbations [ 19] were most probably due to redox-sensitive machineries not directly regulating transcription of other core histone genes.
Our studies introduced the NAD(H) coenzymes into the picture and demonstrated that they can significantly modulate H2B transcription and the interaction between Oct-1 and OCA-S, and possibly other redox-sensitive machineries.
We proposed a redox signalling system that gates H2B expression, coordinates the expression of other histone genes and affects other redox-sensitive machineries to dictate S-phase progression; indeed, perturbing the redox eventually led to an activation of intra-S-phase checkpoint(s) to hamper S-phase progression [ 19].
Superoxide dismutases act as part of the cellular antioxidant system protecting the redox sensitive cellular machinery from damage induced by reactive oxygen species (ROS).
Furthermore, sigma-1 receptors form Ca2+-sensitive chaperone machinery with another chaperone, BiP, and prolong Ca2+ signaling from ER into mitochondria by stabilizing IP3 receptors at mitochondrion-associated ER membrane [17].
Further studies based on pharmacologic inhibition and RNAi-mediated knockdown of distinct c-Jun upstream regulators are therefore required to gain further insights into the probably complex redox-sensitive molecular machinery that links KRIT1 to the ROS-mediated activation of c-Jun.
The translation machinery is exquisitely sensitive to PSCs that terminate the process of protein elongation.
Therefore, more sensitive and higher resolution MS machinery is definitely preferred for future consideration.
Homologous recombination (HR) is a critical pathway for DNA double-strand break repair; cells with compromised HR machinery are highly sensitive to DNA-damaging drugs [ 4].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com