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So too is sensitivity and specificity, where sensitive linkage refers to assigning the records to the correct individual; specificity refers to assigning all records from a single individual to a single individual.
The release rate of encapsulated drugs depends upon the pH value and pH sensitive linkage in the backbone of copolymers.
In vivo anti-tumor activity of conjugates containing hydrolytically sensitive linkage was also significantly improved in mouse EL4 T cell lymphoma.
Indeed, as enzyme-sensitive linkages are introduced in such self-regulating systems, the active compound is only released in presence of the microorganisms that secrete the specific enzymes that can cleave the sensitive linkage in the construction (e.g. lipases (Komnatnyy et al. 2014)).
Cell wall proteins (CWP) are either covalently linked to the cell wall β (1,6 -glucans by a glycophosphatidylinositol (GPI) moiety or linked via an alkali sensitive linkage to β (1,6 -glucans.
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A doxorubicin conjugated prodrug incorporated acid-sensitive linkage between drug and Pluronic F127-chitosan (F127-CS) polymer was successfully synthesized.
The hydrophobic PS, Verte, was covalently incorporated onto the surfaces of the AuNP conjugates through a pH-sensitive linkage, which increased the water solubility of Verte from < 1 μg/ml to > 2000 μg/ml.
It should be noted that there are two known types of covalently cell-wall associated proteins in S. cerevisiae, namely those linked to the β-1,3-glucan matrix through an unknown alkali-sensitive linkage, and those linked to the same matrix in a glycosylphosphatidylinositol- (GPI-) dependent manner [8].
This strategy involved the use of a light-sensitive linkage to introduce a caging moiety onto therapeutic or imaging agents, thus darkening their bioactivities.
In the case of polymer drug conjugates, pH-sensitive linkages, such as oxime (pH < 5), hydrazone (pH < 5), hydrazide (pH < 5) and acetal (pH < 4 5), have been used to directly attach drug molecules to polymers.
Silyl ethers are widely studied acid-sensitive linkages.
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Justyna Jupowicz-Kozak
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