Resistant cancer cell types may be predominant in MRD, whereas in metastatic disease abundant sensitive cells initially respond.
In three replica microhabitat-experiments, sensitive cells initially showed some growth but ceased growth before resistant and producer cells did (see Figure 6).
This could be explained by the insufficient presence of JAK2V617F in the proportion of examined cells, making the mutation undetectable at that instance, considering that the amount of mutated cells was already at the detection threshold of our sensitive assay initially.
We note, however, that the observed time course is roughly consistent with the time scale of "fast" adaptation in cones, which restores a large part of the light-sensitive current initially turned off at the peak of the response to a step of light[19].
Prolyl hydroxylase domain proteins PHD1, PHD2, and PHD3 (codified by EGLN2, EGLN1, and EGLN3, respectively) are oxygen-sensitive enzymes initially known for their ability to target the hypoxia-inducible transcriptional factors HIF-1α and HIF-2α for proteasomal degradation (Epstein et al, 2001).
In fact, some tumours are intrinsically resistant to many kinds of chemotherapeutic agents, whereas other tumours, initially sensitive, often recur or become resistant not only to the initial agents used but also to those used subsequently.
After repeated treatment, initially sensitive lung tumors became resistant to bortezomib.
Similarly to human B-TNBC, HCC1806-RR tumors were initially sensitive to taxane therapy but subsequently recur.
Much of T.A.O.'s work is labeled E.C.I., for "exceptionally controlled information," material so sensitive it was initially stored only in safes.
