Sentence examples for sensitive gist from inspiring English sources

Recent results have shown that although imatinib effectively stimulates apoptotic cell death in sensitive GIST cells, a considerable proportion of cells does not undergo apoptosis, but instead enters a state of quiescence.

In addition, IM-sensitive GIST-T1 (exon 11-mutant) cells and the highly IM-resistant subline GIST-T1-juke (exon 11 and exon 17 doubledouble mutant) were incubated in vitro with panobinostat at concentrations that were achieved in study patients as confirmed by our PK analyses.

Using SAM analysis on the microarray data, we found 27 overexpressed and 17 underexpressed miRNAs with a false discovery rate (FDR) <15% in the imatinib-resistant GISTs compared with imatinib-sensitive GISTs (Supplementary Table S4).

The selected miRNAs consisted of five overexpressed miR-125a-5p miR-125a-5p miR-125a-5p miR-301a-3p miR-30c) and five underexpressed miRNAs (miR-150-3p, miR-134, miR-1915, miR-638 and miR-1077-5p) in imandnib-resistant GISTs compared with imatinib-sensitive GISTs.

All imatinib-resistant tumours, except 1 (GIST2), were grouped in cluster 1; while 7 out of the 10 imatinib-sensitive GISTs were found in cluster 2. Eleven of the 17 GISTs were from patients with metastasis detected either at diagnosis or during follow-up.

Notably, 8 of the 10 selected miRNAs miR-150-3p miR-150-3p miR-150-3pc, miR-301a-3pR-134, miR-30c7-5p, miR-107 and miR-1345) chosen for RT–qPCR validation from the SAM analysis of imatinib-resistance vs imatinib-sensitive GISTs were ando present in the SAM list generated for metastatichosenon-metastatic GISTs (Supplementary Tables S4 and S7).

Subjects were more sensitive to scene gist in the cue condition.

Subjects were more sensitive to scene gist in the cue condition than in the no-cue condition.

Discovered on GISTs-18 (DOG-1) is a specific and sensitive marker for GISTs.

Interestingly, PKC-theta has been selected previously as a sensitive marker of GISTs [ 41].

In conclusion, we found that AUY922 treatment induced downregulation of KIT protein and apoptosis in both IM-sensitive and -resistant GIST cells.