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Also new is the unfortunately named Force Touch, a pressure sensitive functionality that sounds like it's fairly similar to Apple's 3D Touch offering.
An unanticipated benefit of the phase-transfer protocol was an improved tolerance toward sensitive functionality.
Notably, the cross-coupling of siloxane 1 e, which features a primary TBS ether, gave 5 ae and be under fluoride-free conditions without deprotection of the TBS group, demonstrating compatibility with this commonly employed fluoride/acid sensitive functionality.
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The resultant catalyst is the most effective catalyst reported, up to now, for hydrogenating nitroaromatic compounds in the presence of other sensitive functionalities.
Notably, the aromatic aldehydes possessing highly sensitive functionalities such as 4-benzyloxy benzaldehyde (Table 1, entry 8) also reacted smoothly to give a good yield of the corresponding product.
Second, a stimulus-sensitive functionality that responds to alterations in the environment, such as pH, ionic strength or the presence of metal ions, is often needed to control structural conversion and to shift the equilibrium in either direction.
Generally low yields, long reaction times, and limitation to use acid- or base-sensitive functionality in carbonyl compounds are the major limitations of these methods.
In this Article, we report on a pH-responsive and charge-neutral polymer nanogel that stably encapsulates an enzyme at neutral pH and then releases it at low pH using β-thioesters as the stimulus-sensitive functionality in the cross-linker of the nanogel.
Most photo-responsive materials possess light-sensitive functionalities, Table 3, such as azobenzene, spiropyran or nitrobenzyl groups [51, 52].
These strongly basic conditions are incompatible with base-sensitive functionalities, such as esters.
The latter is compatible with base- and acid-sensitive functionalities, such as acetal protecting groups, imides, and esters, but not N-acetates.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com