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Exact(4)
This analysis differs from determining recessive CNVs classified as dosage sensitive, dosage insensitive, or dosage reversed in homozygous PS2.
Sensitive dosage effect of the puromycin selection system could be advantageous for the tight selection of the expression level of pac.
Although HCCS is ubiquitously expressed (Schaefer et al, 1996; Schwarz & Cox, 2002), the highly specific clinical features observed in MLS affected females suggest a critical function and a sensitive dosage for HCCS in the eye and the skin.
Moreover, we analyzed the sensitive dosage of the dnd-MO injection, and revealed that the complete depletion of PGCs was generated as the injected dnd-MO dosage was up to 1000 pg/embryo, in which no any germ cells were observed at the 24 hpf embryos (Additional file 2: Figure S2).
Similar(56)
The interaction data set from BIOGRID (Stark et al. 2006; http://thebiogrid.org/) was used to detect protein protein interactions for dosage-sensitive, dosage-insensitive, recessive and nonrecessive CNV genes in different context.
Dosage sensitive genes and dosage resistant genes are enriched with different functional pathways.
This suggests a response that is less sensitive to dosage.
This construct is not sensitive to dosage compensation (see Figure 2B).
Interestingly, the expression level of all six of these genes was often sensitive to dosage of other regions and showed tissue-specific differences.
We also did not notice a correlation between the expression level of a gene and its likelihood to be sensitive to dosage changes.
The overcompensation of X-linked genes in the male brain might be enhanced relative to other tissues, if the brain is more sensitive to dosage compensation.
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