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Combining parasite density distribution data with infectivity data allows us to estimate how much of the infectious reservoir will be detectable with more sensitive diagnostics.
This could indicate that the reduced sensitivity of microscopy/RDT observed in low transmission settings (Fig. 1d) may be less severe with more sensitive diagnostics.
The application to clinical samples and controls demonstrates that this is a promising technology for fast turn-around times and sensitive diagnostics.
The wealth of quantitative PCR data collated for this study allowed us, for the first time, to investigate how the proportion of infections detected in different transmission settings might be expected to change with more sensitive diagnostics.
The increasing resistance of many microbial strains to antibiotics, delayed laboratory results, and side effects of many chemotherapeutics has raised the need to search for sensitive diagnostics and new prophylactic strategies especially prevention by vaccination.
The unexpected magnitude of this overlap presents the unique opportunity to dissect the pathogenic mechanisms underlying multiple disease states in the expectation that this may lead to both more sensitive diagnostics and novel therapies.
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It requires sensitive diagnostic methods.
Rapid and sensitive diagnostic techniques are desirable.
With a more sensitive diagnostic, the expected drop-off in performance is smaller.
The research confirmed the potential of quantum dot probes for sensitive diagnostic tests, even genetic analysis.
Radiographic techniques are the most sensitive diagnostic methods and esophageal webs may be confused with esophageal stenosis.
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