Wnt agonists/antagonists balance was analyzed after dihydrotestosterone (DHT) stimulation in androgen-sensitive dermal papilla cells (DPC) cultured as spheroids or monolayer.
Interestingly human epidermal keratinocytes that are naturally resistant to UVA-induced damage possess lower intracellular LIP levels than the UVA-sensitive dermal fibroblasts.
In quantitative terms, keratinocytes also release less cytosolic labile iron after UVA than the UVA-sensitive dermal fibroblasts and this has been correlated with their low propensity to undergo UVA-induced necrotic cell death [21].
The sensitive parameters in the dermal only model were DERMDOSE (NSC = 1.0), Aexp (NSC = 1.0), Kuptake (NSC = 1.0), and Po b (NSC = −0.3).
The objective of this review is to describe our current understanding of how redox-sensitive processes may drive dermal tissue repair.
With in vitro studies, it was observed that CXCR4 gene expression and migration of bone mesenchymal stromal cells and hypo-dermal fibroblasts were more sensitive to exogenous SDF-1 alpha, while expression of tendon repair gene markers by hypo-dermal fibroblasts and Achilles tendon fibroblasts were more sensitive to exogenous SDF-1 alpha.
The two layers interdigitate via fingerlike projections (dermal papillae), consisting of sensitive vascular dermis projecting into the epidermis.
Using a sensitivity analysis, it was however shown in Bouchard et al. [ 10] that a NBE based on a 12-h urine collection following the onset of a dermal exposure scenario is sensitive to the highly variable dermal absorption rate of CPF whereas a NBE based on a 12-h urine collection following an oral scenario is much less affected by variations in the oral absorption rate.
Shpn m/m mouse dermal fibroblasts (MDFs) were also sensitive to TNF-induced cell death, and this death was almost completely blocked by the RIPK1 kinase inhibitor Necrostatin-1 (Nec-1), but not by the pan-caspase inhibitor Q-VD-OPh.
Triple A syndrome patient dermal fibroblasts appear to be more sensitive to oxidative stress than wild-type fibroblasts.
Recently, it was demonstrated that primary human dermal microvascular endothelial cells are highly sensitive to as little as 7 ng ml−1 mycolactone (Ogbechi et al., 2015).
