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As a result, more sensitive deep sequencing assays are needed to identify lower frequency off-target mutations (Cho et al., 2014; Fu et al., 2014).
Combining the sensitive deep sequencing methods and these tools it is possible to discover both novel and evolutionary conserved miRNAs [ 16- 18].
The diagnosis of reinfection has traditionally been based on direct Sanger sequencing of samples pre- and posttreatment, but not on more sensitive deep sequencing techniques.
It is possible that these lower-read novel candidates may be new miRNAs revealed by the highly sensitive deep sequencing approach.
One potential reason for this finding is that the highly sensitive deep sequence technology makes it possible to identify novel candidates with lower counts.
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Mr. Abercrombie, the guitarist, has made his name with some sensitive, deep-listening records on the ECM label.
The UCL excites the attached photosensitive drug (Au25 nanoclusters) to generate singlet oxygen (1O2) for photodynamic therapy (PDT), while DCL with strong NIR emission serves as probe for sensitive deep-tissue imaging.
Evaluation by the more sensitive deep-sequencing method revealed a known activating mutation, L1679P, in exon 27 of NOTCH1 in the T-ALL patient with a CR, which was confirmed in an independent bone marrow sample collected at a different time point (25% blasts; Table 2).
The location-sensitive deep network architecture improves the synthesis results significantly compared to the standard multilayer perceptron architecture.
While many sites, including the above, provide details on discounted hotel rooms, EveryLodge is only interested in featuring those which are time-sensitive deep discounts.
The first approach is based on a deep network architecture, referred to as location-sensitive deep network, which integrates spatial information with intensity-based features in a principled manner.
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