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Oestrogen is known to stimulate hormonally sensitive breast cancer.
Tumor derived MCF-7 cells are used to mimic hormone sensitive breast cancers.
We also established that doxorubicin treatment induces proliferation arrest and FOXO3a nuclear relocation in sensitive breast cancer cells.
Paclitaxel induces the nuclear translocation and accumulation of FOXO3a to induce apoptosis in sensitive breast cancer cell lines [22], [27].
In fact, luminal A is recognized as the less sensitive breast cancer subtype to adjuvant chemotherapy.
Endocrine therapy is a highly effective form of adjuvant therapy for hormone sensitive breast cancer.
Similar(42)
The report appears alongside a separate study that found aromatase inhibitors prevented more deaths than tamoxifen in postmenopausal women with hormone-sensitive breast cancers.
The study assessed the history of tamoxifen use among more than 1,000 breast cancer survivors from the Seattle-Puget Sound region who learned they had an estrogen-sensitive breast cancer when they were 40 to 79 years old.
Some experts have questioned whether soy might lower testosterone levels in men and cause problems for women who have estrogen-sensitive breast cancers.
Continuous estrogen suppression in patients with hormone-sensitive breast cancer prevents proliferation of tumor.
17βHSD1 is an attractive drug target in hormone-sensitive breast cancer.
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