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But what about a bisexual or sensitive Bond?
"When equity, bond and convertibles markets are cheap, you buy a long-dated, sensitive bond; when they're expensive, buy a short-dated, insensitive bond," he says.
At present, the reduction sensitive bond is widely used in the drug/gene delivery system.
However, since aggrecan cleavage at the MMPs sensitive bond is also detectable in OA cartilage [ 56], MMPs may also act on aggrecan later in the progression of disease.
All samples were processed using a sensitive 'Bond polymer Refine' detection system in an automated Bond immunohistochemistry instrument (Vision-Biosystem, Menarini, Florence, Italy).
Similar(54)
The design of the internally quenched substrates is such that the calpain-sensitive bond of the peptides (between the Tyr-Gly residues) is located centrally between the donor and the quencher chromophores.
PEG-hyd-DOX released the least amount of DOX probably because it incorporates an acid-sensitive bond between DOX and PEG.
All the above-mentioned concerning unique characteristics of intracellular conditions and tumor microenvironments offer new hope to screen a redox-sensitive bond for development of a reduction-sensitive drug carrier [ 21– 23].
At the same time, nanoparticle binding to VLA-4 triggers receptor-mediated uptake, which results in active Dox release due to pH-sensitive bond hydrolysis in the acidic endocytic vesicles.
Although a significant difference in the AUC0→∞ values of DOX from PEG-ami-DOX and PEG-hyd-DOX was found (P < 0.05), the DOX-PEG conjugates existed for longer periods in the blood than did DOX and DOX-LNA, during which time the introduction of the pH-sensitive bond in PEG-hyd-DOX markedly decreased the release of DOX in the blood.
They are a good way to balance out a portfolio heavy in interest-rate-sensitive bonds.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com