Both polycarbonates have acid sensitive backbones; therefore, when combined with an acid source, catalyzed decomposition was observed within minutes, achieving a range of decomposition temperatures between 160 °C and 250 °C.
The amide I band in infrared spectroscopy is very sensitive to backbone conformation and is able to distinguish several structural motifs (48– 52).
Consequently, this technique is sensitive to backbone vibrational modes as well as certain side chain modes (i.e., arginine, aspartates, glutamates, and tyrosine) being perturbed, and as a result, one can identify changes in these modes as a function of the perturbation.
To investigate if differences in local secondary structure contribute to the HN chemical shift differences observed between Aβ43 and Aβ42, JHN-Hα coupling constants sensitive to backbone ϕ angles were obtained by line-shape analysis of high-resolution H HSQC spectra.
The release rate of encapsulated drugs depends upon the pH value and pH sensitive linkage in the backbone of copolymers.
Based on the salicylic acid backbone, three highly sensitive and selective colorimetric chemosensors with an acylthiourea binding unit have been designed, synthesized and characterized.
Laurdan is a fluorescent probe that locates in the phospholipids glycerol backbone and is sensitive to polarity changes and dynamic properties at membrane's lipid water interface.
The amphiphilic copolymers possess a fluorescent hydrophobic P NVK-co-VBC) backbone and P NVK-co-VBC hydroP NVK-co-VBCEMA-co-AAc) side chains.
Second, with structure sensitive energy functions, whether and how backbone flexibility is considered can have large effects on design accuracy, although usually only small adjustments of the backbone structure itself are involved.
Because the infrared measurements are sensitive to changes in the peptide backbone, they are able to capture subtle changes and do not rely on a side chain reporter.
