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Novel sensitive approaches to detect leukemia relapse through next-generation sequencing of mutated hotspots such as FLT3-ITD and NPM1 are currently in development [ 8].
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Nevertheless, it represents a sensitive approach to detect differences between patient and control in the key parameters of ΔΨm.
Together, mapping the functional integrity of the human brain in neurological or psychiatric conditions emerges as a noninvasive sensitive approach to detect alterations in neuronal signaling.
RPKM level measurement is a sensitive approach to detect expression level, that measures expression of even poorly expressed transcripts using read count as the fundamental.
WGS coverage is limited due to cost and this technique cannot be as sensitive as targeted approaches to detect low subclonal variants (AF <0.1).
In this work Makarova and co-workers have first performed an updated analysis of cas proteins using genomic context analysis and sensitive methods (iteration approaches) to detect low level of similarity and to classify cas proteins in families and superfamilies.
To consider the impact of fluctuating population size on the rate of adaptation and to infer how different approaches to detect selection are sensitive to such fluctuations (and thus show a different dependency on the long-term vs. current population size), we utilize a forward simulation approach, and condition on the demographic parameters estimated with dadi (see Results).
Ligation-based systems seem very promising approaches to detect GMOs in a multiplex setting in a sensitive and specific way.
To address the first of these two questions, we evaluated migration of HB1.F3.C1 cells to tumor cells in bone marrow, using a sensitive molecular approach to detect the presence of minimal numbers of tumors cells and/or HB1.F3.C1 cells.
Using surface-bound peptide nucleic acids (PNA) probes and soluble fluorescent cationic polythiophenes, we show a simple and sensitive electrostatic approach to detect and identify unlabelled target nucleic acid on microarray.
The developed system provides a rapid, sensitive and accurate approach to detect pathogens in practice samples.
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