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This paper introduces what is defined as a sensitising model.
The second objective of this paper is thus to present the design rationale of such an exploration in order to produce a sensitising model for safety assessments.
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Other adjuvants that have been used in sensitising animal models include heat-killed Bordetella pertussis, raisins, and adjuvant mixes such as Freund's complete adjuvant [ 22].
Consistent with these observations, treatment with the same insulin sensitising agents in experimental models attenuated learning and memory deficits [32], reduced the accumulation of Aβ, reduced Aβ42 levels and reduced levels of inflammatory markers [33].
In another study, researchers used a combination of allergens in a single animal model; animals were sensitised either with single, double, or triple allergens (HDM, ragweed, Aspergillus fumigatus) [ 34].
The most recent findings from a breast cancer study revealed that DKK3 not only attenuates tumour growth in a xenotransplantation mouse model, it also re-sensitised multidrug-resistant MCF7/ADR cells to doxorubicin treatment in a JNK-c-Jun dependent manner [ 26].
The theory thus is used more as an analytical framework or sensitising concept [35] in this paper.
The rapid progress and promising achievements in the field of apoptosis systems biology and apoptosis sensitising therapeutics may serve as a 'raw model' to facilitate this in the coming years.
In this study, we investigate the effects of inhibiting the AQP in sensitising human prostate cancer cells to cryotherapy using an in vitro model.
This clearly shows the ability of the rabbit to develop disease from the point of being sensitised through adulthood, thus making this species ideal as a model for human asthma.
Following this encouraging first step, we report here a set of experiments that extend this concept to an in vivo model, specifically the normal skin of hairless mice sensitised with ALA-PpIX.
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