Sentence examples for sensitising effect from inspiring English sources

The UV sensitising effect of DRB seems to be related to an increase in UV-associated DNA damage.

Pre-treatment with 25  μ O6-BG sensitised four out of the five tested neuroblastoma cell lines to TMZ by 0.3 1.4 logs; sensitising effect was not demonstrated in the highly drug-resistant CHLA-90 cells that lack MGMT expression.

To confirm the etoposide sensitising effect of the AS RNA-mediated reductiof of GSTP1 expression in A375-ASPi1 cells, we tested whether inhibition of GST activity by the GST inhibitors curcumin (Harbottle et al, 2001) and ethacrynic acid (O'Dwyer et al, 1991) would also sensitise these cells.

The rationale for investigating the sensitising effect of quercetin on CLL derives from previous works on leukaemic cell lines showing the apoptogenic activity of the molecule on cell lines resistant to DR-induced cell death (Russo et al, 1999, 2003, 2007).

The effect would probably be weak, since those same brains are already exposed to alcohol and tobacco, which have the same sensitising effect.

Since we see increased levels of DSBs in irs1SF cells in combination with downregulation of RAD51-mediated HR repair, we would expect that DRB following UV treatment would have a stronger sensitising effect on HR defective cells in comparison to the wild type cells.

Alcohol and nicotine have the same "cross-sensitising" effect.

Although, the magnitude of the UV-sensitising effect of DRB decreases in G1 arrested cells (Figure 2), the relative DRB sensitisations remain similar as compared to exponentially growing cells (Figure S2).

Surprisingly, we find that DRB has no UV-sensitising effect in HR defective cells, despite the fact that these cells contain more 53BP1 foci and are unable to repair the UV/DRB lesion, as observed by their inability to form RAD51 foci.

This is in apparent contrast to the long-term glucose-lowering, insulin-sensitising effect of rosiglitazone.

These effects may be due to the myocardium-sensitising effect of halothane and the sympathomimetic effect of CO2.