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At follow-up, a further 20 patients had reduced their exposure to the sensitising agent.
Metformin is an insulin sensitising agent which is known to improve vascular health outcomes in type 2 diabetes (T2D) and other individuals with insulin resistance.
29 Only one participant developed a ≥20% fall in FEV1 on exposure to a degreasing spray that apparently did not contain a known sensitising agent.
No known sensitising agent was identified in one participant who had been challenged with a cleaning product that contained sodium octylsulfate, nitrilotriacetic acid and potassium hydroxide.
The reasons for this must be determined and may potentially be overcome by manipulation and optimisation of the plasma parameters (Cheng et al, 2014) and/or pretreatment with a sensitising agent (Frame et al, 2013).
The present study confirms that the prognosis of OA is poor in participants who remain exposed to the sensitising agent, as shown by the persistence of symptoms and airway hyper-responsiveness in many patients.
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Therefore, in order to design truly effective insulin sensitising agents, targeted at the mechanism of disease development, we aimed to generate an obesity-related insulin resistant cell model.
Consistent with these observations, treatment with the same insulin sensitising agents in experimental models attenuated learning and memory deficits [32], reduced the accumulation of Aβ, reduced Aβ42 levels and reduced levels of inflammatory markers [33].
For these effects non-steroidal anti-inflammatory drugs have been recently employed as sensitising agents in chemotherapy.
Insulin sensitising agents are commonly used as adjunctive medications for women with PCOS and metformin is widely chosen.
The effects of photosensitiser alone on SLs are expected to be less pronounced, with more potent sensitising agents administered at much lower doses than Photofrin.
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