Sentence examples for sensitising activity from inspiring English sources

For this reason there is a need to develop and apply appropriate animal models that will offer a more holistic view of sensitising activity.

Therefore, we investigate here whether the sensitising activity of this flavonoid, which leads to increased apoptosis in both cell lines and CLL, could be related to Mcl-1 expression and stability.

Using a suitable cell line, we demonstrated the sensitising activity of quercetin.

Adiponectin has among other effects direct insulin-sensitising activity and a protective role in the development of CVD [ 34, 35].

It indicates that DCA sensitised anticancer activities of sorafenib against HCC through an ERK signalling-independent mechanism.

They also found that selective inhibition of PI3K or AKT activity sensitised MCF7 breast cancer cells to the induction of apoptosis by chemotherapeutic agents.

In subsequent mechanistic analysis reported here, we have now established that DUSP6 depletion has a broader activity in sensitising cells not only to EGFR inhibitors but also to additional targeted agents and to DNA-damaging agents.

Special efforts should be made to ensure that gender is mainstreamed in all government policies, including the Poverty Reduction Strategy Paper (PRSP), programming processes and related activities, by sensitising all personnel and developing their gender analysis skills.

The current study has also shown that despite the ability of MDM2 p53 antagonists to affect MDR-1 activity and sensitise high MDR-1-expressing cells to MDR-1 substrates, combining MDM2 p53 antagonists, Nutlin-3, NDD005, MI-63 and RG7388 with verapamil did not further sensitise p53 wt high MDR-1-expressing SHSY5Y cells to the MDM2 p53 antagonists.

Previous pre-clinical and clinical observations have suggested that Hsp90 inhibitors may be most effective when used as 'chemomodulators', exploiting their reported capacity to reduce NF- κB activity to sensitise metastatic cancer cells to chemotherapeutic and biological agents such as oxaliplatin and TRAIL (Rakitina et al, 2003).

Currently, the BKB activities sensitise to raise the awareness, knowledge, skills, and attitudes of parents and other family members in fostering growth and development of baby and toddlers.