For this reason there is a need to develop and apply appropriate animal models that will offer a more holistic view of sensitising activity.
Therefore, we investigate here whether the sensitising activity of this flavonoid, which leads to increased apoptosis in both cell lines and CLL, could be related to Mcl-1 expression and stability.
Adiponectin has among other effects direct insulin-sensitising activity and a protective role in the development of CVD [ 34, 35].
It indicates that DCA sensitised anticancer activities of sorafenib against HCC through an ERK signalling-independent mechanism.
Currently, the BKB activities sensitise to raise the awareness, knowledge, skills, and attitudes of parents and other family members in fostering growth and development of baby and toddlers.
Special efforts should be made to ensure that gender is mainstreamed in all government policies, including the Poverty Reduction Strategy Paper (PRSP), programming processes and related activities, by sensitising all personnel and developing their gender analysis skills.
In subsequent mechanistic analysis reported here, we have now established that DUSP6 depletion has a broader activity in sensitising cells not only to EGFR inhibitors but also to additional targeted agents and to DNA-damaging agents.
They also found that selective inhibition of PI3K or AKT activity sensitised MCF7 breast cancer cells to the induction of apoptosis by chemotherapeutic agents.
Finally, another strategy to improve the cytotoxic activity of parthenolide on breast cancer cells could consist in its combination with other compounds capable of sensitising the cells to parthenolide action.
Other socio-cultural theories, such as situated learning and communities of practice (Lave and Wenger 1991; Wenger 1998) provide some additional sensitising concepts as they focus, more than activity theory, on the development of independence in such settings.
