In ZAG-overexpressing transgenic mice, which exhibit decreased body weight and epididymal fat, mRNA levels of HSL in adipose tissue are elevated and the tissue is sensitised to the action of catecholamines (Gong et al, 2009).
The capacity of 17-AAG to reduce the activation of NF- κB has been proposed as a potential mode of action in sensitising cancer cells to oxaliplatin and 5-FU (Rakitina et al, 2003).
8 Current oral medications endorsed by ADA and EASD treatment algorithms for treating patients with type 2 diabetes, that is, metformin, sulfonylureas, dipeptidyl peptidase 4 inhibitors and thiazolidinediones, act by increasing insulin secretion or sensitising tissues to insulin action.
Traditional healers should be sensitised and trained, and action should be taken against unsafe practices.
Adiponectin is an adipose tissue secreted protein known for its insulin sensitising and anti-atherogenic actions.
It has been suggested that cells become apoptotic following escape from G2M blockade, and it may be that such cells are then sensitised to the actions of alkylating agents such as temozolomide.
Finally, another strategy to improve the cytotoxic activity of parthenolide on breast cancer cells could consist in its combination with other compounds capable of sensitising the cells to parthenolide action.
The former include replacing the lost function of tumour suppressor genes, inhibiting the action of activated oncogenes, sensitising tumour cells to prodrugs, or infecting the tumoral tissue with viruses that replicate selectively in cancer cells.
The single-agent activity of rituximab, coupled with its distinct mechanisms of action, nonoverlapping toxicity and ability to sensitise lymphoma cells to cytotoxic activity, has encouraged researchers to evaluate combinations of rituximab with chemotherapy.
However, even this additional stressor could not sensitise SiHa cells to increased cytolysis by the combined action of TNF-α and histamine.
