Sentence examples for sensitisation of cells from inspiring English sources
These cell specific responses to GNPs have the potential to provide a biological mechanism for the sensitisation of cells to the effects of ionising radiation.
This is supported by Cygb knockdown studies showing sensitisation of cells to oxidative stress, with over-expression providing protection.
Selective sensitisation of cells with G1 checkpoint dysfunction by ATR inhibitors may therefore only be seen when comparing normal and cancerous cells.
Histone deacetylase 1 (but not HDAC3, HDAC6, or HDAC8) was recently also demonstrated to be responsible for sensitisation of cells to TRAIL-induced apoptosis (Inoue et al, 2006).
By contrast, two other Bcl-xL-, Bcl-2 and Bcl-w-inhibitors – gossypol and TW-37 – were ineffective in the sensitisation of cells to IAV-induced death.
Our present observations suggest that suramin may possibly result in sensitisation of cells to ionising radiation by inactivation of DNA-PK and the impairment of DSBs repair.
In this study, we have shown that pharmacological inhibition of CXCR2 signalling results in a cell-dependent sensitisation of PC3 cells but not DU145 cells to the Hsp90 inhibitors, GA and 17-AAG.
The above data show that HIF-1 has divergent effects on radiosensitivity: sensitisation of tumour cells and protection of stromal endothelial cells.
These findings suggest that the functional cell surface expression of TRAIL-R2 on #63 glioma cells by genotoxic agents is the essential mechanism of sensitisation of #63 cells to TRAIL, and the subsequent death signal through TRAIL-R2 induces apoptosis of #63 cells via activation of caspases.
The importance of activation of both types of signalling in sensitisation of cancer cells to TRAIL has been recently shown for prostate cancer cells (Ray and Almasan, 2003).
It is thus feasible that a p53-mediated process contributes to α-TOS-induced DR5 upregulation in MM cells, consistent with another report suggesting p53 activation as a mode of sensitisation of cancer cells towards TRAIL killing (Xie et al, 2001).
