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bioconcentration in fish, skin sensitisation, mutagenicity, carcinogenicity, developmental toxicity.
CAESAR developed new QSAR models specific for REACH for these endpoints: bioconcentration in fish, skin sensitisation, mutagenicity, carcinogenicity, developmental toxicity.
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Covalent binding of xenobiotic electrophiles to nucleophilic endogenous biomolecules, e.g. peptides or DNA, is a common molecular initiating event, leading to potentially irreversible toxic effects such as enhanced acute toxicity, skin sensitisation, or mutagenicity.
The impact of generic and endpoint specific sources of variability has been highlighted in a proof-of-principle analysis considering the variation in protocols for assays for four human health endpoints (skin sensitisation, reproductive/developmental toxicity, mutagenicity and carcinogenicity).
CAESAR developed several models for five endpoints: BCF, mutagenicity, carcinogenicity, developmental toxicity and skin sensitisation.
Genetic toxicology Role of mutagenicity in fiber-induced carcinogenicity Is there a mutagenic MOA? Mutagenicity/carcinogenicity at low doses.
Sensitisation is detectable by reaction to a skin-prick test.
These range from more CCTV cameras in city centres to gender sensitisation lessons for schoolchildren.
She and other activists are also contacting colleges to help run gender sensitisation classes.
But much longer-term support, strengthening and community sensitisation will be needed.
After several weeks of sensitisation, mobilisation and assessments, the people have been anxious to see real action.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com