Here, we report a sensitisation model with long term airway allergen challenges which induce typical features of chronic asthma including protracted changes in lung function, airway inflammation, mucus hyperplasia and peribronchial fibrosis.
A behavioural sensitisation model would imply that suicide attempts would be repeated throughout the episodes.
A behavioural sensitisation or kindling model has been proposed for suicidal behaviour, in accordance with a sensitisation model of depressive episodes.
In the quinpirole sensitisation rat model of OCD, the model compulsive behavior is induced by repeated injections of quinpirole that result in sensitisation of DA receptors (Szechtman et al., 1998, 1999).
That analysis of the quinpirole sensitisation rat model of OCD reported that the model compulsive behavior consisted of at least three partially independent processes, all greatly exaggerated by quinpirole – vigor of checking performance, focus on the task of checking, and satiety following a bout of checking (Dvorkin et al., 2010).
This successful synthesis of quinpirole-like compulsive checking behavior by a non-quinpirole method suggests relatively strongly that the previously identified three constitutive components do indeed underlie OCD behavior in the quinpirole sensitisation rat model.
A previous analysis of the quinpirole sensitisation rat model of obsessive-compulsive disorder revealed that the behavioral phenotype of compulsive checking consists of three constitutive components – vigor of checking performance, focus on the task of checking, and satiety following a bout of checking.
The results of these studies indicate that QSAR skin sensitisation classification models using a fairly small number of simple descriptors can be constructed using either AFP or MLP, which will have good predictive power, especially for those compounds with some degree of sensitisation potential.
A weak association was observed for the number of pairs of powdered latex gloves used in the last 7 days with both latex sensitisation and LA (models III and IV).
In summary, we report a mouse model of sensitisation followed by long term allergen challenges leading to sustained allergic airway inflammation, goblet cell hyperplasia, peribronchial fibrosis, and impaired lung function.
We have employed an experimental protocol using repeated, prolonged inhaled administration of HDM, in the absence of experimental adjuvants or peripheral sensitisation, to more faithfully model the exposure to allergen experienced by asthmatic patients.
