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Triptans are no longer fully effective for migraine therapy after central sensitisation has developed [58].
Central sensitisation has previously been suggested to be important not only in TTH [57 63], FMS and SNP [16, 64, 65], but also in migraine [66 68].
Computer programs such as Derek [2] are used to share human knowledge about mammalian toxicity and a proof of concept application, Eco-Derek, using the same technology to share knowledge about toxicity to the ciliate Tetrahymena pyriformis and human skin sensitisation has been described [3].
Involvement of cytoskeleton in pain sensitisation has been anticipated for a long time, as microtubule-based chemotherapeutics against cancer are known to induce severe long-lasting neuropathic pain [94].
38 Lowered PPT in asymptomatic areas, indicating general sensitisation, has also been found in patients with Ehlers-Danlos syndrome.
For schistosome antigens, in utero sensitisation has been shown to occur in up to 50% of human neonates whose mothers had schistosomiasis [ 6, 10].
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Both global and local QSAR models for skin sensitisation have been developed.
The QSAR models for assessing skin sensitisation have been developed and tested under stringent quality criteria to fulfil the principles laid down by the OECD.
As documented in the recent OECD report 'the adverse outcome pathway for skin sensitisation initiated by covalent binding to proteins' (OECD, 2012), the chemical and biological events driving the induction of human skin sensitisation have been investigated for many years and are now well understood.
Consequently the prevalence of latex sensitisation may have been underestimated as it is possible that HCWs who had already developed latex sensitisation have left the hospital before the study was conducted.
Perspectives of immunotherapy to cancer mediated by bone marrow transplantation (BMT) in conjunction with dendritic cell (DC -mediated immune sensitisation have yielDC -mediateduccess so far.
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