Exact(5)
A previously published fragmentation method for making reliable negative in silico predictions has been applied to the problem of predicting skin sensitisation in humans, making use of a dataset of over 2750 chemicals with publicly available skin sensitisation data from 18 in vivo assays.
Table 6 Subdivisions of the skin sensitisation data set into binary classes.
Avocado (OR 12.3; 95% CI 5.1 to 29.6) and others (OR 5.1; 95% CI 2.1 to 11.8) which included pineapple and orange showing significant associations with latex sensitisation (data not shown).
We used information from the clinical investigative subsample, in which 91% of the children were tested either by SPT or blood sample, regardless of the presence of symptoms, to conduct multiple imputations on missing sensitisation data.
We could not obtain detailed information on certain variables such as atopic sensitisation data or smoking history (eg, duration or the number of cigarettes a day) but we assumed these data to be missing at random (ie, it is subject to non-differential misclassification bias for comparison groups of interest).
Similar(55)
Because reported sensitisation was not considered missing at random, sensitisation-data from the subsample, where all of the randomly selected participants included were tested regardless of the presence of disease symptoms, were used as predictors in the ICE command.
The RANTES levels in BAL also correlated with viral load in the same compartment (ρ = 0.635, p = 0.011, Fig. 4D), whereas elevated RANTES levels were not associated with M. tuberculosis sensitisation status (data not shown).
With regard to co-sensitisation HDM/SM, our data demonstrated that 94% of exposed workers have co-sensitisation, but we hypothesised that this is not only attributable to cross-reaction, because 88% of controls are sensitised to HDM but not to SM.
Other limitations include not having the individual data on sensitisation to tree pollen (skin prick or allergen specific IgE) and medication use as well as socioeconomic status.
Indeed, recent data observing sensitisation to cisplatin using HIF-targeting RNAi suggest that reversal of hypoxic resistance is p53 dependent (Hao et al, 2008).
Scientific and social science methods were used to collect data, following full sensitisation of the communities.
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