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Community sensitisation, as a component of community engagement, plays an important role in strengthening the ethics of community-based trials in developing countries and is fundamental to trial success.
First, the concept of central sensitisation as a cause of chronic pain will be explained.
We defined sensitisation as a positive skin prick test to at least one of the allergens assessed.
Other groups, for example working in drama, connect with agencies as part of their community sensitisation: As a drama group, we access condoms at the [main] centre and carry some with us.
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If mass testing is introduced as described in Scenario 1 and a test sensitivity of 99.7% can be achieved [ 16], this will mean that £54,086 can be saved at the price of each additional sensitisation, as long as a zero royalty fee applies.
Knowledge about the presence of central sensitisation as an underlying pain mechanism may be useful for rheumatologists when treating patients with few obvious signs of inflammation and a high DAS28-CRP score primarily derived from patient reported information, such as high tender joint count and/or persistent pain.
It has been hypothesised that the course of the disease is different for those with sensitisation as opposed to those without sensitisation, and that rather than a progressive atopic march, there are different phenotypes of eczema leading to asthma [ 3, 24].
A key 'go/no-go' step in this assessment will be an evaluation of the relative degree of sensitisation (as measured by SER) of tumour vs normal tissues.
Early wheezing in infancy is not a major predictor of childhood asthma, 26 and we did not have any data on allergic sensitisation as measured by IgE.
This limitation was deemed necessary in order to include sufficient numbers of patients likely to have features of sensitisation, as we know pain sensitisation is related to pain intensity.
3 4 It is recognised that chronic pain may alter central pain processing, for example, central sensitisation, as the continuous damage of the pancreatic nerves may in time lead to central sensitisation of the pain system.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com